Increased Expression of Cytotoxic T-Lymphocyte−Associated Protein 4 by T Cells, Induced by B7 in Sera, Reduces Adaptive Immunity in Patients With Acute Liver Failure

BACKGROUND & AIMS: Patients with acute liver failure (ALF) have defects in innate immune responses to microbes (immune paresis) and are susceptible to sepsis. Cytotoxic T-lymphocyte−associated protein 4 (CTLA4), which interacts with the membrane receptor B7 (also called CD80 and CD86), is a nega...

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Dettagli Bibliografici
Pubblicato in:Gastroenterology
Autori principali: Khamri, Wafa, Abeles, Robin D., Hou, Tie Zheng, Anderson, Amy E., El-Masry, Ahmed, Triantafyllou, Evangelos, Bernsmeier, Christine, Larsen, Fin S., Singanayagam, Arjuna, Kudo, Nobuaki, Possamai, Lucia A., Lebosse, Fanny, Auzinger, Georg, Bernal, William, Willars, Christopher, Weston, Christopher J., Lombardi, Giovanna, Wendon, Julia, Thursz, Mark, Antoniades, Charalambos G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: W.B. Saunders 2017
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516432/
https://ncbi.nlm.nih.gov/pubmed/28363639
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.03.023
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