Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis

The gain-of-function mucin 5B (MUC5B) promoter variant, rs35705950, confers the largest risk, genetic or otherwise, for the development of idiopathic pulmonary fibrosis; however, the mechanisms underlying the regulation of MUC5B expression have yet to be elucidated. Here, we identify a critical regu...

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Vydáno v:Am J Respir Cell Mol Biol
Hlavní autoři: Helling, Britney A., Gerber, Anthony N., Kadiyala, Vineela, Sasse, Sarah K., Pedersen, Brent S., Sparks, Lenore, Nakano, Yasushi, Okamoto, Tsukasa, Evans, Christopher M., Yang, Ivana V., Schwartz, David A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2017
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5516283/
https://ncbi.nlm.nih.gov/pubmed/28272906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2017-0046OC
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