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Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling

BACKGROUND: The physiological regulation of G protein-coupled receptors, through desensitization and internalization, modulates the length of the receptor signal and may influence the development of tolerance and dependence in response to chronic drug treatment. To explore the importance of receptor...

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Detalhes bibliográficos
Main Authors: Scearce-Levie, Kimberly, Lieberman, Michael D, Elliott, Heather H, Conklin, Bruce R
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC551613/
https://ncbi.nlm.nih.gov/pubmed/15707483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-3-3
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