GSK-3β deletion in dentate gyrus excitatory neuron impairs synaptic plasticity and memory

Increasing evidence suggests that glycogen synthase kinase-3β (GSK-3β) plays a crucial role in neurodegenerative/psychiatric disorders, while pan-neural knockout of GSK-3β also shows detrimental effects. Currently, the function of GSK-3β in specific type of neurons is elusive. Here, we infused AAV-C...

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Pubblicato in:Sci Rep
Autori principali: Liu, Enjie, Xie, Ao-Ji, Zhou, Qiuzhi, Li, Mengzhu, Zhang, Shujuan, Li, Shihong, Wang, Weijin, Wang, Xiaochuan, Wang, Qun, Wang, Jian-Zhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515925/
https://ncbi.nlm.nih.gov/pubmed/28720858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06173-4
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