Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

BACKGROUND: Studies combining immune checkpoint inhibitors with external beam radiation have shown a therapeutic advantage over each modality alone. The purpose of these works is to evaluate the potential of targeted delivery of high LET radiation to the tumor microenvironment via an immune checkpoi...

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Detalles Bibliográficos
Publicado en:EJNMMI Res
Main Authors: Nedrow, Jessie R., Josefsson, Anders, Park, Sunju, Bäck, Tom, Hobbs, Robert F., Brayton, Cory, Bruchertseifer, Frank, Morgenstern, Alfred, Sgouros, George
Formato: Artigo
Idioma:Inglês
Publicado: Springer Berlin Heidelberg 2017
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515722/
https://ncbi.nlm.nih.gov/pubmed/28721684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-017-0303-2
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