Pharmacokinetics, microscale distribution, and dosimetry of alpha-emitter-labeled anti-PD-L1 antibodies in an immune competent transgenic breast cancer model

BACKGROUND: Studies combining immune checkpoint inhibitors with external beam radiation have shown a therapeutic advantage over each modality alone. The purpose of these works is to evaluate the potential of targeted delivery of high LET radiation to the tumor microenvironment via an immune checkpoi...

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Bibliografiska uppgifter
I publikationen:EJNMMI Res
Huvudupphovsmän: Nedrow, Jessie R., Josefsson, Anders, Park, Sunju, Bäck, Tom, Hobbs, Robert F., Brayton, Cory, Bruchertseifer, Frank, Morgenstern, Alfred, Sgouros, George
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Berlin Heidelberg 2017
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515722/
https://ncbi.nlm.nih.gov/pubmed/28721684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-017-0303-2
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