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Paclitaxel-induced painful neuropathy is associated with changes in mitochondrial bioenergetics, glycolysis, and an energy deficit in dorsal root ganglia neurons

Painful neuropathy is the major dose-limiting side effect of paclitaxel chemotherapy. Mitochondrial dysfunction and adenosine triphosphate (ATP) deficit have previously been shown in peripheral nerves of paclitaxel-treated rats, but the effects of paclitaxel in the dorsal root ganglia (DRGs) have no...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Duggett, Natalie A., Griffiths, Lisa A., Flatters, Sarah J.L.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515641/
https://ncbi.nlm.nih.gov/pubmed/28541258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000939
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