Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria

The first synthesis of octapeptin C4 was achieved using a combination of solid phase synthesis and off-resin cyclisation. Octapeptin C4 displayed antibiotic activity against multi-drug resistant, NDM-1 and polymyxin-resistant Gram-negative bacteria, with moderate activity against Staphylococcus aure...

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Detaylı Bibliyografya
Yayımlandı:Bioorg Med Chem Lett
Asıl Yazarlar: Becker, Bernd, Butler, Mark S., Hansford, Karl A., Gallardo-Godoy, Alejandra, Elliott, Alysha G., Huang, Johnny X., Edwards, David J., Blaskovich, Mark A. T., Cooper, Matthew A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515593/
https://ncbi.nlm.nih.gov/pubmed/28454673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.04.027
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