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Synthesis of octapeptin C4 and biological profiling against NDM-1 and polymyxin-resistant bacteria
The first synthesis of octapeptin C4 was achieved using a combination of solid phase synthesis and off-resin cyclisation. Octapeptin C4 displayed antibiotic activity against multi-drug resistant, NDM-1 and polymyxin-resistant Gram-negative bacteria, with moderate activity against Staphylococcus aure...
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| Pubblicato in: | Bioorg Med Chem Lett |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5515593/ https://ncbi.nlm.nih.gov/pubmed/28454673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.04.027 |
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