Octapeptin C4 and polymyxin resistance occur via distinct pathways in an epidemic XDR Klebsiella pneumoniae ST258 isolate

BACKGROUND: Polymyxin B and E (colistin) have been pivotal in the treatment of XDR Gram-negative bacterial infections; however, resistance has emerged. A structurally related lipopeptide, octapeptin C4, has shown significant potency against XDR bacteria, including polymyxin-resistant strains, but it...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Pitt, Miranda E, Cao, Minh Duc, Butler, Mark S, Ramu, Soumya, Ganesamoorthy, Devika, Blaskovich, Mark A T, Coin, Lachlan J M, Cooper, Matthew A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6376851/
https://ncbi.nlm.nih.gov/pubmed/30445429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dky458
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