Reciprocal regulation of ARPP-16 by PKA and MAST3 kinases provides a cAMP-regulated switch in protein phosphatase 2A inhibition

ARPP-16, ARPP-19, and ENSA are inhibitors of protein phosphatase PP2A. ARPP-19 and ENSA phosphorylated by Greatwall kinase inhibit PP2A during mitosis. ARPP-16 is expressed in striatal neurons where basal phosphorylation by MAST3 kinase inhibits PP2A and regulates key components of striatal signalin...

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Vydáno v:eLife
Hlavní autoři: Musante, Veronica, Li, Lu, Kanyo, Jean, Lam, Tukiet T, Colangelo, Christopher M, Cheng, Shuk Kei, Brody, A Harrison, Greengard, Paul, Le Novère, Nicolas, Nairn, Angus C
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Computational and Systems Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515580/
https://ncbi.nlm.nih.gov/pubmed/28613156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.24998
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