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Eg5 inhibitors have contrasting effects on microtubule stability and metaphase spindle integrity
To uncover their contrasting mechanisms, antimitotic drugs that inhibit Eg5 (kinesin-5) were analyzed in mixed-motor gliding assays of kinesin-1 and Eg5 motors in which Eg5 “braking” dominates motility. Loop-5 inhibitors (monastrol, STLC, ispinesib and filanesib) increased gliding speeds, consistent...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5515541/ https://ncbi.nlm.nih.gov/pubmed/28165699 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01040 |
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