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Eg5 inhibitors have contrasting effects on microtubule stability and metaphase spindle integrity

To uncover their contrasting mechanisms, antimitotic drugs that inhibit Eg5 (kinesin-5) were analyzed in mixed-motor gliding assays of kinesin-1 and Eg5 motors in which Eg5 “braking” dominates motility. Loop-5 inhibitors (monastrol, STLC, ispinesib and filanesib) increased gliding speeds, consistent...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Chen, Geng-Yuan, Kang, You Jung, Gayek, A. Sophia, Youyen, Wiphu, Tüzel, Erkan, Ohi, Ryoma, Hancock, William O.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515541/
https://ncbi.nlm.nih.gov/pubmed/28165699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01040
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