Decreased gastrointestinal toxicity associated with a novel capecitabine schedule (7 days on and 7 days off): a systematic review

Capecitabine is widely used in the management of metastatic breast cancer; however, drug delivery is limited by gastrointestinal and other toxicity. We employed mathematical modeling to rationally design an optimized dose and schedule for capecitabine of 2,000 mg twice daily, flat dosing, 7 days on,...

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Bibliographic Details
Published in:NPJ Breast Cancer
Main Authors: Cadoo, Karen A, Gajria, Devika, Suh, Emily, Patil, Sujata, Theodoulou, Maria, Norton, Larry, Hudis, Clifford A, Traina, Tiffany A
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5515341/
https://ncbi.nlm.nih.gov/pubmed/28721374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjbcancer.2016.6
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