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Optimizing Chemotherapy Dose and Schedule by Norton-Simon Mathematical Modeling

BACKGROUND: To hasten and improve anticancer drug development, we created a novel approach to generating and analyzing preclinical dose-scheduling data so as to optimize benefit-to-toxicity ratios. METHODS: We applied mathematical methods based upon Norton-Simon growth kinetic modeling to tumor-volu...

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Detalhes bibliográficos
Main Authors: Traina, Tiffany A., Dugan, Ute, Higgins, Brian, Kolinsky, Kenneth, Theodoulou, Maria, Hudis, Clifford A., Norton, Larry
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228251/
https://ncbi.nlm.nih.gov/pubmed/20519801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/BD-2009-0290
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