Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency

Enforced ectopic expression of a cocktail of pluripotency-associated genes such as Oct4, Sox2, Klf4 and c-Myc can reprogram somatic cells into induced pluripotent stem cells (iPSCs). The remarkable proliferation ability of iPSCs and their aptitude to redifferentiate into any cell lineage makes these...

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Enregistré dans:
Détails bibliographiques
Publié dans:Epigenomics
Auteurs principaux: van den Hurk, Mark, Kenis, Gunter, Bardy, Cedric, van den Hove, Daniel L, Gage, Fred H, Steinbusch, Harry W, Rutten, Bart P
Format: Artigo
Langue:Inglês
Publié: Future Medicine Ltd 2016
Sujets:
Review
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514980/
https://ncbi.nlm.nih.gov/pubmed/27419933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/epi-2016-0032
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