Targeting of the breast cancer microenvironment with a potent and linkable oxindole based antiangiogenic small molecule

The clinical efficacy of antiangiogenic small molecules (e.g., sunitinib) in breast carcinoma has largely failed with substantial off-target toxicity. We rationally designed and evaluated preclinically a novel sunitinib analogue, SAP, with favourable pharmacological properties and the ability to be...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Argyros, Orestis, Karampelas, Theodoros, Varela, Aimilia, Asvos, Xenophon, Papakyriakou, Athanasios, Agalou, Adamantia, Beis, Dimitris, Davos, Constantinos H., Fokas, Demosthenes, Tamvakopoulos, Constantin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514907/
https://ncbi.nlm.nih.gov/pubmed/28422745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16763
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