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Epithelial cell specific Raptor is required for initiation of type 2 mucosal immunity in small intestine

Intestinal tuft cells are one of 4 secretory cell linages in the small intestine and the source of IL-25, a critical initiator of the type 2 immune response to parasite infection. When Raptor, a critical scaffold protein for mammalian target of rapamycin complex 1 (mTORC1), was acutely deleted in in...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Aladegbami, Bola, Barron, Lauren, Bao, James, Colasanti, Jason, Erwin, Christopher R., Warner, Brad W., Guo, Jun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514129/
https://ncbi.nlm.nih.gov/pubmed/28717211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-06070-w
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