Glucagon-like peptide-1 reduces pancreatic β-cell mass through hypothalamic neural pathways in high-fat diet-induced obese rats

We examined whether glucagon-like peptide-1 (GLP-1) affects β-cell mass and proliferation through neural pathways, from hepatic afferent nerves to pancreatic efferent nerves via the central nervous system, in high-fat diet (HFD)-induced obese rats. The effects of chronic administration of GLP-1 (7–3...

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Publicado no:Sci Rep
Main Authors: Ando, Hisae, Gotoh, Koro, Fujiwara, Kansuke, Anai, Manabu, Chiba, Seiichi, Masaki, Takayuki, Kakuma, Tetsuya, Shibata, Hirotaka
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5514038/
https://ncbi.nlm.nih.gov/pubmed/28717164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05371-4
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