The Dipeptidyl Peptidase-4 Inhibitor Des-Fluoro-Sitagliptin Regulates Brown Adipose Tissue Uncoupling Protein Levels in Mice with Diet-Induced Obesity

OBJECTIVE: Dipeptidyl peptidase (DPP)-4 is responsible for the degradation of several peptides that contain an alanine or proline at the penultimate position or position P1. DPP-4 inhibitors (DPP-4is) have protective effects against type-2 diabetes and several metabolic disorders. METHODS: In the pr...

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Main Authors: Shimasaki, Takanobu, Masaki, Takayuki, Mitsutomi, Kimihiko, Ueno, Daisuke, Gotoh, Koro, Chiba, Seiichi, Kakuma, Tetsuya, Yoshimatsu, Hironobu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656085/
https://ncbi.nlm.nih.gov/pubmed/23696840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0063626
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