Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin.

Proliferation and immunologic function of T lymphocytes are initiated by signals from the antigen receptor that are inhibited by the immunosuppressant FK506 but not by its structural analog, rapamycin. On the other hand, interleukin 2 (IL-2)-induced signals are blocked by rapamycin but not by FK506....

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bierer, B E, Mattila, P S, Standaert, R F, Herzenberg, L A, Burakoff, S J, Crabtree, G, Schreiber, S L
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55138/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2123553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.23.9231
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