Pyrin-only protein 2 limits inflammation but improves protection against bacteria

Pyrin domain-only proteins (POPs) are recently evolved, primate-specific proteins demonstrated in vitro as negative regulators of inflammatory responses. However, their in vivo function is not understood. Of the four known POPs, only POP2 is reported to regulate NF-κB-dependent transcription and mul...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Periasamy, Sivakumar, Porter, Kristen A., Atianand, Maninjay K., T. Le, Hongnga, Earley, Sarah, Duffy, Ellen B., Haller, Matthew C., Chin, Heather, Harton, Jonathan A.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512670/
https://ncbi.nlm.nih.gov/pubmed/28580947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15564
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