Pyrin-only protein 2 limits inflammation but improves protection against bacteria

Pyrin domain-only proteins (POPs) are recently evolved, primate-specific proteins demonstrated in vitro as negative regulators of inflammatory responses. However, their in vivo function is not understood. Of the four known POPs, only POP2 is reported to regulate NF-κB-dependent transcription and mul...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Periasamy, Sivakumar, Porter, Kristen A., Atianand, Maninjay K., T. Le, Hongnga, Earley, Sarah, Duffy, Ellen B., Haller, Matthew C., Chin, Heather, Harton, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512670/
https://ncbi.nlm.nih.gov/pubmed/28580947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15564
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