Host copper-mediated oxidative antimicrobial offense is countered by Aspergillus fumigatus copper export machinery and reactive oxygen intermediate defense

The Fenton-chemistry generating properties of copper ions are considered a potent phagolysosome defense against pathogenic microbes, yet our understanding of underlying host/microbe dynamics remains unclear. We address this issue in invasive aspergillosis and demonstrate that host and fungal respons...

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Udgivet i:Cell Rep
Main Authors: Wiemann, Philipp, Perevitsky, Adi, Lim, Fang Yun, Shadkchan, Yana, Knox, Benjamin P., Landero Figueora, Julio A., Choera, Tsokyi, Niu, Mengyao, Steinberger, Andrew J., Wüthrich, Marcel, Idol, Rachel A., Klein, Bruce S., Dinauer, Mary C., Huttenlocher, Anna, Osherov, Nir, Keller, Nancy P.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512462/
https://ncbi.nlm.nih.gov/pubmed/28467895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.019
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