3-Hydroxykynurenine, a Tryptophan Metabolite Generated during the Infection, Is Active Against Trypanosoma cruzi

[Image: see text] The antiparasitic activity of 3-hydroxykynurenine (3-HK), one of the major tryptophan catabolites of the kynurenine pathway, against both Trypanosoma cruzi evolutive forms that are important for human infection, trypomastigotes (Tps) and amastigotes (Am), possible targets in the pa...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Knubel, Carolina P., Insfran, Constanza, Martinez, Fernando F., Diaz Lujan, Cintia, Fretes, Ricardo E., Theumer, Martin G., Cervi, Laura, Motran, Claudia C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512135/
https://ncbi.nlm.nih.gov/pubmed/28740612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00169
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