Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: a Phase 1 Clinical Trial

PURPOSE: Invariant NKT cells (iNKT) are innate-like CD1d-restricted T cells with immunoregulatory activity in diseases including cancer. iNKT from advanced cancer patients can have reversible defects including IFN-gamma production, and iNKT IFN-gamma production may stratify for survival. Previous cl...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Exley, Mark A., Friedlander, Phillip, Alatrakchi, Nadia, Vriend, Lianne, Yue, Simon, Sasada, Tetsuro, Zeng, Wanyong, Mizukami, Yo, Clark, Justice, Nemer, David, LeClair, Kenneth, Canning, Christine, Daley, Heather, Dranoff, Glenn, Giobbie-Hurder, Anita, Hodi, F. Stephen, Ritz, Jerome, Balk, Steven P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511564/
https://ncbi.nlm.nih.gov/pubmed/28193627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-0600
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