Manipulation of nuclear architecture through CRISPR-mediated chromosomal looping

Chromatin looping is key to gene regulation, yet no broadly applicable methods to selectively modify chromatin loops have been described. We have engineered a method for chromatin loop reorganization using CRISPR-dCas9 (CLOuD9) to selectively and reversibly establish chromatin loops. We demonstrate...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Morgan, Stefanie L., Mariano, Natasha C., Bermudez, Abel, Arruda, Nicole L., Wu, Fangting, Luo, Yunhai, Shankar, Gautam, Jia, Lin, Chen, Huiling, Hu, Ji-Fan, Hoffman, Andrew R., Huang, Chiao-Chain, Pitteri, Sharon J., Wang, Kevin C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511349/
https://ncbi.nlm.nih.gov/pubmed/28703221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15993
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