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Brain specific Lamellipodin knockout results in hyperactivity and increased anxiety of mice

Lamellipodin (Lpd) functions as an important signalling integrator downstream of growth factor and axon guidance receptors. Mechanistically, Lpd promotes actin polymerization by interacting with F-actin and the actin effectors Ena/VASP proteins and the SCAR/WAVE complex. Thereby, Lpd supports lamell...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Bodo, Cristian, Fernandes, Cathy, Krause, Matthias
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511208/
https://ncbi.nlm.nih.gov/pubmed/28710397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05043-3
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