Intrinsic dynamics study identifies two amino acids of TIMP-1 critical for its LRP-1-mediated endocytosis in neurons

The tissue inhibitor of metalloproteinases-1 (TIMP-1) exerts inhibitory activity against matrix metalloproteinases and cytokine-like effects. We previously showed that TIMP-1 reduces neurite outgrowth in mouse cortical neurons and that this cytokine-like effect depends on TIMP-1 endocytosis mediated...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Verzeaux, Laurie, Belloy, Nicolas, Thevenard-Devy, Jessica, Devy, Jérôme, Ferracci, Géraldine, Martiny, Laurent, Dedieu, Stéphane, Dauchez, Manuel, Emonard, Hervé, Etique, Nicolas, Devarenne-Charpentier, Emmanuelle
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511134/
https://ncbi.nlm.nih.gov/pubmed/28710453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05039-z
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