Real-time monitoring of conformational transitions of single-molecule histone deacetylase 8 with nanocircuits()

Using single-molecule approaches, we directly observed the dynamic interaction between HDAC8 and various ligands as well as conformational interconversions during the catalytic reaction. Statistical analysis identified key kinetic parameters, demonstrating that the enzymatic activity is highly sensi...

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Bibliografiske detaljer
Udgivet i:Chem Commun (Camb)
Main Authors: You, Seungyong, Froberg, James, Yu, Junru, Haldar, Manas, Sedigh, Abbas, Mallik, Sanku, Srivastava, D. K., Choi, Yongki
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510773/
https://ncbi.nlm.nih.gov/pubmed/28261707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6cc09949a
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