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Dual targeting of EWS-FLI1 activity and the associated DNA damage response with Trabectedin and SN38 synergistically inhibits Ewing sarcoma cell growth

PURPOSE: The goal of this study is to optimize the activity of trabectedin for Ewing sarcoma by developing a molecularly targeted combination therapy. EXPERIMENTAL DESIGN: We have recently shown that trabectedin interferes with the activity of EWS-FLI1 in Ewing sarcoma cells. In this report, we buil...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Clin Cancer Res
Päätekijät: Grohar, Patrick J., Segars, Laure E., Yeung, Choh, Pommier, Yves, D’Incalci, Maurizio, Mendoza, Arnulfo, Helman, Lee J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510643/
https://ncbi.nlm.nih.gov/pubmed/24277455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-13-0901
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