An iridium(iii)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent

Bromodomain-containing protein 4 (BRD4) has recently emerged as an attractive epigenetic target for anticancer therapy. In this study, an iridium(iii) complex is reported as the first metal-based, irreversible inhibitor of BRD4. Complex 1a is able to antagonize the BRD4-acetylated histone protein–pr...

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Detalles Bibliográficos
Publicado en:Chem Sci
Main Authors: Zhong, Hai-Jing, Lu, Lihua, Leung, Ka-Ho, Wong, Catherine C. L., Peng, Chao, Yan, Siu-Cheong, Ma, Dik-Lung, Cai, Zongwei, David Wang, Hui-Min, Leung, Chung-Hang
Formato: Artigo
Idioma:Inglês
Publicado: Royal Society of Chemistry 2015
Assuntos:
Chemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510529/
https://ncbi.nlm.nih.gov/pubmed/28757943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc02321a
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