Glucocorticoid Receptor:MegaTrans Switching Mediates Repression of an ERα-Regulated Transcriptional Program

The molecular mechanisms underlying the opposing functions of glucocorticoid receptors (GR) and estrogen receptor α (ERα) in breast cancer development remain poorly understood. Here, we report that in breast cancer cells liganded GR represses a large ERα-activated transcriptional program by binding,...

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Publicat a:Mol Cell
Autors principals: Yang, Feng, Ma, Qi, Liu, Zhijie, Li, Wenbo, Tan, Yuliang, Jin, Chunyu, Ma, Wubin, Hu, Yiren, Shen, Jia, Ohgi, Kenneth A., Telese, Francesca, Rosenfeld, Michael G.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510478/
https://ncbi.nlm.nih.gov/pubmed/28475868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.03.019
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