The Effects of Inherited NUDT15 Polymorphisms on Thiopurine Active Metabolites in Japanese Children with Acute Lymphoblastic Leukemia

Thiopurines (e.g., mercaptopurine [MP]) are widely used chemotherapeutic agents in the treatment of pediatric acute lymphoblastic leukemia (ALL) with dose-limiting hematopoietic toxicity. Recently, germline variants in NUDT15 have been identified as a major genetic cause for MP-related bone marrow s...

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Udgivet i:Pharmacogenet Genomics
Main Authors: Moriyama, Takaya, Nishii, Rina, Lin, Ting-Nien, Kihira, Kentaro, Toyoda, Hidemi, Nersting, Jacob, Kato, Motohiro, Koh, Katsuyoshi, Inaba, Hiroto, Manabe, Atsushi, Schmiegelow, Kjeld, Yang, Jun J., Hori, Hiroki
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510236/
https://ncbi.nlm.nih.gov/pubmed/28445187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FPC.0000000000000282
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