Adipocyte adaptive immunity mediates diet-induced adipose inflammation and insulin resistance by decreasing adipose Treg cells

Obesity leads to a switch in subsets of CD4(+) T cell in adipose tissue, characterized by an increase in IFNγ producing Th1 cells and a decrease in anti-inflammatory regulatory T (Treg) cells, which impairs systemic insulin sensitivity. What signals these changes is unknown. Herein we demonstrate th...

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Publicat a:Nat Commun
Autors principals: Deng, Tuo, Liu, Joey, Deng, Yanru, Minze, Laurie, Xiao, Xiang, Wright, Valerie, Yu, Richeng, Li, Xian C., Blaszczak, Alecia, Bergin, Stephen, DiSilvestro, David, Judd, Ryan, Bradley, David, Caligiuri, Michael, Lyon, Christopher J., Hsueh, Willa A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510177/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15725
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