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Defining the noninferiority margin and analysing noninferiority: An overview

Noninferiority trials are used to assess whether the effect of a new drug is not worse than an active comparator by more than a noninferiority margin. If the difference between the new drug and the active comparator does not exceed this prespecified margin, noninferiority can be concluded. This marg...

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Bibliografiske detaljer
Udgivet i:Br J Clin Pharmacol
Main Authors: Althunian, Turki A., de Boer, Anthonius, Groenwold, Rolf H. H., Klungel, Olaf H.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510081/
https://ncbi.nlm.nih.gov/pubmed/28252213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13280
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