Large‐conductance Ca(2+)‐activated K(+) channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium

KEY POINTS: Hydrocortisone (HC) is required for activation of large‐conductance Ca(2+)‐activated K(+) current (BK) by purinergic receptor agonists. HC reduces insertion of the stress‐regulated exon (STREX) in the KCNMA1 gene, permitting protein kinase C (PKC)‐dependent channel activation. Overlappin...

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Vydáno v:J Physiol
Hlavní autoři: Zaidman, Nathan A., Panoskaltsis‐Mortari, Angela, O'Grady, Scott M.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Molecular and Cellular
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509885/
https://ncbi.nlm.nih.gov/pubmed/28481415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274200
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