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Large‐conductance Ca(2+)‐activated K(+) channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium
KEY POINTS: Hydrocortisone (HC) is required for activation of large‐conductance Ca(2+)‐activated K(+) current (BK) by purinergic receptor agonists. HC reduces insertion of the stress‐regulated exon (STREX) in the KCNMA1 gene, permitting protein kinase C (PKC)‐dependent channel activation. Overlappin...
Gorde:
| Argitaratua izan da: | J Physiol |
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| Egile Nagusiak: | , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
John Wiley and Sons Inc.
2017
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5509885/ https://ncbi.nlm.nih.gov/pubmed/28481415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP274200 |
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