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An extremely high dietary iodide supply forestalls severe hypothyroidism in Na(+)/I(−) symporter (NIS) knockout mice
The sodium/iodide symporter (NIS) mediates active iodide (I(−)) accumulation in the thyroid, the first step in thyroid hormone (TH) biosynthesis. Mutations in the SLC5A5 gene encoding NIS that result in a non-functional protein lead to congenital hypothyroidism due to I(−) transport defect (ITD). IT...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5509730/ https://ncbi.nlm.nih.gov/pubmed/28706256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04326-z |
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