Elovanoids are novel cell-specific lipid mediators necessary for neuroprotective signaling for photoreceptor cell integrity

Docosahexaenoic acid (DHA, 22:6 n-3) is abundant in the retina and is enzymatically converted into pro-homeostatic docosanoids. The DHA- or eicosapentaenoic acid (EPA)-derived 26 carbon fatty acid is a substrate of elongase ELOVL4, which is expressed in photoreceptor cells and generates very long ch...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jun, Bokkyoo, Mukherjee, Pranab K., Asatryan, Aram, Kautzmann, Marie-Audrey, Heap, Jessica, Gordon, William C., Bhattacharjee, Surjyadipta, Yang, Rong, Petasis, Nicos A., Bazan, Nicolas G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509689/
https://ncbi.nlm.nih.gov/pubmed/28706274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05433-7
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