CAMK2γ in Intestinal Epithelial Cells Modulates Colitis-Associated Colorectal Carcinogenesis via Enhancing STAT3 Activation

Inflammation is one of the major risk factors for cancer. Here, we show that calcium/calmodulin-dependent protein kinase II gamma (CAMK2γ) in intestinal epithelial cells (IECs) modulates inflammatory signals and promotes colitis-associated cancer (CAC) in mice. We have identified CAMK2γ as a downstr...

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Pubblicato in:Oncogene
Autori principali: Ma, Xiaoxiao, Meng, Zhipeng, Jin, Lihua, Xiao, Zhenzhou, Wang, Xiaoqiong, Tsark, Walter M., Ding, Lili, Gu, Ying, Zhang, Jiawei, Kim, Byungwook, He, Min, Gan, Xiaoxian, Shively, John E, Yu, Hua, Xu, Rongzhen, Huang, Wendong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509478/
https://ncbi.nlm.nih.gov/pubmed/28319059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.16
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