Spatial analysis of Cdc42 activity reveals a role for plasma membrane–associated Cdc42 in centrosome regulation

The ability of the small GTPase Cdc42 to regulate diverse cellular processes depends on tight spatial control of its activity. Cdc42 function is best understood at the plasma membrane (PM), where it regulates cytoskeletal organization and cell polarization. Active Cdc42 has also been detected at the...

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Udgivet i:Mol Biol Cell
Main Authors: Herrington, Kari A., Trinh, Andrew L., Dang, Carolyn, O’Shaughnessy, Ellen, Hahn, Klaus M., Gratton, Enrico, Digman, Michelle A., Sütterlin, Christine
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2017
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509425/
https://ncbi.nlm.nih.gov/pubmed/28539409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E16-09-0665
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