Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages

BACKGROUND: Drugs such as isoniazid (INH) and pretomanid (PRT), used against Mycobacterium tuberculosis are active partly through generation of reactive nitrogen species (RNS). The aim of this study was to explore variability in intracellular susceptibility to nitric oxide (NO) in clinical strains o...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Idh, Jonna, Andersson, Blanka, Lerm, Maria, Raffetseder, Johanna, Eklund, Daniel, Woksepp, Hanna, Werngren, Jim, Mansjö, Mikael, Sundqvist, Tommy, Stendahl, Olle, Schön, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509328/
https://ncbi.nlm.nih.gov/pubmed/28704501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181221
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