Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages

BACKGROUND: Drugs such as isoniazid (INH) and pretomanid (PRT), used against Mycobacterium tuberculosis are active partly through generation of reactive nitrogen species (RNS). The aim of this study was to explore variability in intracellular susceptibility to nitric oxide (NO) in clinical strains o...

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Udgivet i:PLoS One
Main Authors: Idh, Jonna, Andersson, Blanka, Lerm, Maria, Raffetseder, Johanna, Eklund, Daniel, Woksepp, Hanna, Werngren, Jim, Mansjö, Mikael, Sundqvist, Tommy, Stendahl, Olle, Schön, Thomas
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509328/
https://ncbi.nlm.nih.gov/pubmed/28704501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181221
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