Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells

The X-linked inhibitor of apoptosis (XIAP) is a viable molecular target for anticancer drugs that overcome apoptosis-resistance of malignant cells. XIAP is an inhibitor of apoptosis, mediating through its association with BIR3 domain of caspase 9. Embelin, a quinone derivative isolated from the Embe...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Prabhu, Kirti S., Siveen, Kodappully S., Kuttikrishnan, Shilpa, Iskandarani, Ahmad, Tsakou, Magdalini, Achkar, Iman W., Therachiyil, Lubna, Krishnankutty, Roopesh, Parray, Aijaz, Kulinski, Michal, Merhi, Maysaloun, Dermime, Said, Mohammad, Ramzi M., Uddin, Shahab
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2017
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509148/
https://ncbi.nlm.nih.gov/pubmed/28704451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180895
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