Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells

The X-linked inhibitor of apoptosis (XIAP) is a viable molecular target for anticancer drugs that overcome apoptosis-resistance of malignant cells. XIAP is an inhibitor of apoptosis, mediating through its association with BIR3 domain of caspase 9. Embelin, a quinone derivative isolated from the Embe...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Prabhu, Kirti S., Siveen, Kodappully S., Kuttikrishnan, Shilpa, Iskandarani, Ahmad, Tsakou, Magdalini, Achkar, Iman W., Therachiyil, Lubna, Krishnankutty, Roopesh, Parray, Aijaz, Kulinski, Michal, Merhi, Maysaloun, Dermime, Said, Mohammad, Ramzi M., Uddin, Shahab
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509148/
https://ncbi.nlm.nih.gov/pubmed/28704451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180895
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