Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells

The X-linked inhibitor of apoptosis (XIAP) is a viable molecular target for anticancer drugs that overcome apoptosis-resistance of malignant cells. XIAP is an inhibitor of apoptosis, mediating through its association with BIR3 domain of caspase 9. Embelin, a quinone derivative isolated from the Embe...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS One
Egile Nagusiak: Prabhu, Kirti S., Siveen, Kodappully S., Kuttikrishnan, Shilpa, Iskandarani, Ahmad, Tsakou, Magdalini, Achkar, Iman W., Therachiyil, Lubna, Krishnankutty, Roopesh, Parray, Aijaz, Kulinski, Michal, Merhi, Maysaloun, Dermime, Said, Mohammad, Ramzi M., Uddin, Shahab
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2017
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509148/
https://ncbi.nlm.nih.gov/pubmed/28704451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180895
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