Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis

Sphingosine-1-phosphate (S1P) is a biologically active sphingolipid metabolite which has been implicated in many diseases including cancer and inflammatory diseases. Recently, sphingosine kinase 1 (SK1), one of the isozymes which generates S1P, has been implicated in the development and progression...

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Bibliographic Details
Published in:Prostaglandins Other Lipid Mediat
Main Authors: Pulkoski-Gross, Michael J., Uys, Joachim D., Orr-Gandy, K. Alexa, Coant, Nicolas, Bialkowska, Agnieszka B., Szulc, Zdzislaw M., Bai, Aiping, Bielawska, Alicja, Townsend, Danyelle M., Hannun, Yusuf A., Obeid, Lina M., Snider, Ashley J.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5509055/
https://ncbi.nlm.nih.gov/pubmed/28377281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.prostaglandins.2017.03.006
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