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Effect of Calcium Carbonate Encapsulation on the Activity of Orally Administered CpG Oligonucleotides
Synthetic oligodeoxynucleotides containing unmethylated CpG motifs (CpG ODNs) stimulate immune cells via Toll-like receptor 9 (TLR9). Because oligodeoxynucleotides (ODNs) are susceptible to gastric degradation, clinical trials designed to evaluate their therapeutic utility have relied solely on pare...
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| Publicado en: | Mol Ther Nucleic Acids |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society of Gene & Cell Therapy
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5508619/ https://ncbi.nlm.nih.gov/pubmed/28918025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.06.015 |
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