Somatic chromosomal engineering identifies BCAN-NTRK1 as a potent glioma driver and therapeutic target

The widespread application of high-throughput sequencing methods is resulting in the identification of a rapidly growing number of novel gene fusions caused by tumour-specific chromosomal rearrangements, whose oncogenic potential remains unknown. Here we describe a strategy that builds upon recent a...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Cook, Peter J., Thomas, Rozario, Kannan, Ram, de Leon, Esther Sanchez, Drilon, Alexander, Rosenblum, Marc K., Scaltriti, Maurizio, Benezra, Robert, Ventura, Andrea
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508201/
https://ncbi.nlm.nih.gov/pubmed/28695888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15987
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