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The self-inhibitory nature of metabolic networks and its alleviation through compartmentalization
Metabolites can inhibit the enzymes that generate them. To explore the general nature of metabolic self-inhibition, we surveyed enzymological data accrued from a century of experimentation and generated a genome-scale enzyme-inhibition network. Enzyme inhibition is often driven by essential metaboli...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5508129/ https://ncbi.nlm.nih.gov/pubmed/28691704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16018 |
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