Argonaute Utilization for miRNA Silencing Is Determined by Phosphorylation-Dependent Recruitment of LIM-Domain-Containing Proteins

As core components of the microRNA-induced silencing complex (miRISC), Argonaute (AGO) proteins interact with TNRC6 proteins, recruiting other effectors of translational repression/mRNA destabilization. Here, we show that LIMD1 coordinates the assembly of an AGO-TNRC6 containing miRISC complex by bi...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Bridge, Katherine S., Shah, Kunal M., Li, Yigen, Foxler, Daniel E., Wong, Sybil C.K., Miller, Duncan C., Davidson, Kathryn M., Foster, John G., Rose, Ruth, Hodgkinson, Michael R., Ribeiro, Paulo S., Aboobaker, A. Aziz, Yashiro, Kenta, Wang, Xiaozhong, Graves, Paul R., Plevin, Michael J., Lagos, Dimitris, Sharp, Tyson V.
Format: Artigo
Language:Inglês
Published: Cell Press 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507773/
https://ncbi.nlm.nih.gov/pubmed/28683311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.06.027
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