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Challenges in the evaluation of thiol-reactive inhibitors of human protein disulfide isomerase

This paper addresses how to evaluate the efficacy of the growing inventory of thiol-reactive inhibitors of mammalian protein disulfide isomerase (PDI) enzymes under realistic concentrations of potentially competing thiol-containing peptides and proteins. For this purpose, we introduce a variant of t...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Foster, Celia K., Thorpe, Colin
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507595/
https://ncbi.nlm.nih.gov/pubmed/28465261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.04.367
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