A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes

Despite the high response rates of individuals with myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)) to treatment with lenalidomide (LEN) and the recent identification of cereblon (CRBN) as the molecular target of LEN, the cellular mechanism by which LEN eliminates MDS clones...

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Detalhes bibliográficos
Publicado no:Nat Med
Main Authors: Fang, Jing, Liu, Xiaona, Bolanos, Lyndsey, Barker, Brenden, Rigolino, Carmela, Cortelezzi, Agostino, Oliva, Esther N, Cuzzola, Maria, Grimes, H Leighton, Fontanillo, Celia, Komurov, Kakajan, MacBeth, Kyle, Starczynowski, Daniel T
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5507589/
https://ncbi.nlm.nih.gov/pubmed/27294874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4127
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