Myeloid malignancies with chromosome 5q deletions acquire a dependency on an intrachromosomal NF-κB gene network

Chromosome 5q deletions (del(5q)) are common in high-risk (HR) myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML); however, the gene regulatory networks that sustain these aggressive diseases are unknown. Reduced miR-146a expression in del(5q) HR-MDS/AML and miR-146a(−/−) hematopoietic...

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Publicado no:Cell Rep
Main Authors: Fang, Jing, Barker, Brenden, Bolanos, Lyndsey, Liu, Xiaona, Jerez, Andres, Makishima, Hideki, Christie, Susanne, Chen, Xiaoting, Rao, Dinesh S, Grimes, H. Leighton, Komurov, Kakajan, Weirauch, Matthew T., Cancelas, Jose A., Maciejewski, Jaroslaw P., Starczynowski, Daniel T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4237069/
https://ncbi.nlm.nih.gov/pubmed/25199827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.062
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