Ubiquitination of the spliceosome auxiliary factor hnRNPA1 by TRAF6 links chronic innate immune signaling with hematopoietic defects and myelodysplasia

Toll-like receptor (TLR) activation contributes to premalignant hematologic conditions, such as myelodysplastic syndromes (MDS). TRAF6, a TLR-effector with ubiquitin (Ub) ligase activity, is overexpressed in MDS hematopoietic stem/progenitor cells (HSPC). Here we show that TRAF6 overexpression in mo...

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Publicado no:Nat Immunol
Main Authors: Fang, Jing, Bolanos, Lyndsey, Choi, Kwangmin, Liu, Xiaona, Christie, Susanne, Akunuru, Shailaja, Kumar, Rupali, Wang, Dehua, Chen, Xiaoting, Greis, Ken D., Stoilov, Peter, Filippi, Marie-Dominique, Maciejewski, Jaroslaw P., Garcia-Manero, Guillermo, Weirauch, Matthew T., Salamonis, Nathan, Geiger, Hartmut, Zheng, Yi, Starczynowski, Daniel T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423405/
https://ncbi.nlm.nih.gov/pubmed/28024152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3654
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