Lovastatin decreases coenzyme Q levels in rats.
Lovastatin is used for the treatment of hypercholesterolemia. It functions by inhibiting the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34), that is required for the conversion of 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonic acid. Since biosynthesis of both cholesterol a...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
1990
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55073/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2247467/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.22.8928 |
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